Everything about Ototoxicity totally explained
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Ototoxicity is damage of the
ear (
oto), specifically the
cochlea or
auditory nerve and sometimes the
vestibulum, by a
toxin (often
medication).
Causes
A number of drugs have been associated with damage to the
cochlea. The best known are
aminoglycoside antibiotics,
aspirin,
nicotine, some
chemotherapy agents (cisplatin, carboplatin, vincristine) and some
loop diuretics such as
furosemide.
Erythromycin and some other
macrolide antibiotics can induce temporary deafness, which resolves upon withdrawal of the drug.
Other chemicals such as toluene, mercury and carbon monoxide are also known ototoxic chemicals.
There appears to be a hereditary
predisposition to ototoxic reactions.
Symptoms
Symptoms include partial or profound
hearing loss,
vertigo, and
tinnitus.
Treatment
No specific treatment is available, but immediate withdrawal of the drug is warranted.
Further Information
Get more info on 'Ototoxicity'.
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